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Article

Loss of cathepsin L activity promotes claudin-1 overexpression and intestinal neoplasia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2007

Boudreau François, Lussier Carine R, Mongrain Sébastien, Darsigny Mathieu, Drouin Julie L, Doyon Geneviève, Suh Eun Ran, Beaulieu Jean-François, Rivard Nathalie, Perreault Nathalie

Abstract excerpt

Intestinal epithelial integrity and polarity are maintained by cohesive interactions between cells via the formation of tight junctions. Irregularities in tight junctions have only recently been found to be associated with the initiation and progression of intestinal neoplasia. The claudin family of proteins is integral to the structure and function of the tight junction but little is known of the molecular...

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PMID: 17622569
DOI: 10.1096/fj.07-8113com

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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