Article
Overexpression of the paternally expressed gene 10 (PEG10) from the imprinted locus on chromosome 7q21 in high-risk B-cell chronic lymphocytic leukemia.
International journal of cancer - 1 Nov 2007
Kainz Birgit, Shehata Medhat, Bilban Martin, Kienle Dirk, Heintel Daniel, Krömer-Holzinger Elisabeth, Le Trang, Kröber Alexander, Heller Gerwin, Schwarzinger Ilse, Demirtas Dita, Chott Andreas, Döhner Hartmut, Zöchbauer-Müller Sabine, Fonatsch Christa, Zielinski Christoph, Stilgenbauer Stephan, Gaiger Alexander, Wagner Oswald, Jäger Ulrich
Abstract excerpt
We report high expression of the maternally imprinted gene PEG10 in high-risk B-CLL defined by high LPL mRNA expression. Differential expression was initially identified by microarray analysis and confirmed by real time PCR in 42 B-CLL patients. mRNA expression ranged from 0.3- to 375.4-fold compared to normal peripheral blood mononuclear cells (PBMNC). Expression levels in CD19+ B-CLL cells were 100-fold higher...
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