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Article

Silencing of Paternally Expressed Gene 10 Inhibits Trophoblast Proliferation and Invasion

17 Dec 2015

Abstract excerpt

Paternally expressed gene 10 (PEG10) is an imprinted and monoallelic expressed gene. Previous study using a knockout mouse model revealed a crucial role of PEG10 in placental development, yet the exact function of PEG10 during placentation remains to be elucidated. In this study, denuded chorionic villi were prepared from first trimester human placentas, and transduced with PEG10 small interference RNA (siRNA) or...

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PMID: 26680220
DOI: 10.1371/journal.pone.0144845

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