Article
Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population.
Psychiatric genetics - 1 Aug 2007
Iwasaki Shinya, Ishiguro Hiroki, Higuchi Susumu, Onaivi Emmanuel S, Arinami Tadao
Abstract excerpt
BACKGROUND: Fatty acid amide hydrolase (FAAH) and monoglyceride lipase (MGLL) are the major endocannabinoid metabolic enzymes. Owing to the importance of endocannabinoid system in addiction, the Pro129Thr polymorphism in the FAAH gene has reportedly been associated with substance abuse and dependence in a Caucasian population. OBJECTIVE: To determine whether the single nucleodtide polymorphisms of the FAAH and...
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