Article
A missense mutation in human fatty acid amide hydrolase associated with problem drug use.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 2002
Sipe Jack C, Chiang Kyle, Gerber Alexandra L, Beutler Ernest, Cravatt Benjamin F
Abstract excerpt
Problem drug use and dependence are neurobehavioral disorders of complex origin. Although environmental factors contribute to drug abuse and addiction, genetic factors also play a significant role estimated at 40-60% of the total risk. Nonetheless, the precise identities of human genes that confer vulnerability to problem drug use remain mostly unknown. Here, we describe a natural single nucleotide polymorphism...
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