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Article

Association of the Fatty Acid Amide Hydrolase C385A Polymorphism With Alcohol Use Severity and Coping Motives in Heavy-Drinking Youth.

Alcoholism, clinical and experimental research - 1 Mar 2021

Best Laura M, Wardell Jeffrey D, Tyndale Rachel F, McPhee Matthew D, Le Foll Bernard, Kish Stephen J, Boileau Isabelle, Hendershot Christian S

Abstract excerpt

BACKGROUND: Reduced function of fatty acid amide hydrolase, the catabolic enzyme for the endocannabinoid anandamide, can be inherited through a functional genetic polymorphism (FAAH rs324420, C385A, P129T). The minor (A) allele has been associated with reduced FAAH enzyme activity and increased risk for substance use disorders in adults. Whether this inherited difference in endocannabinoid metabolism relates to...

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PMID: 33460184
DOI: 10.1111/acer.14552

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