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Article

2-Methoxy antimycin reveals a unique mechanism for Bcl-x(L) inhibition.

Molecular cancer therapeutics - 1 Jul 2007

Schwartz Pamela S, Manion Michael K, Emerson Christine B, Fry John S, Schulz Craig M, Sweet Ian R, Hockenbery David M

Abstract excerpt

Overexpression of Bcl-x(L) in multiple cancers correlates with resistance to chemotherapy and radiation therapy, and provides a rationale for development of small-molecule Bcl-x(L) inhibitors. Based on knockout studies, nonneoplastic cells also require Bcl-x(L) survival functions, particularly wh...

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PMID: 17620436
DOI: 10.1158/1535-7163.MCT-06-0767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17620436-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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