Article
TLR2 and TLR4 gene polymorphisms and atopic dermatitis in Italian children: a multicenter study.
International journal of immunopathology and pharmacology - 1 Oct 2011
Salpietro C, Rigoli L, Miraglia Del Giudice M, Cuppari C, Di Bella C, Salpietro A, Maiello N, La Rosa M, Marseglia G L, Leonardi S, Briuglia S, Ciprandi G
Abstract excerpt
BACKGROUND Genetic factors have an important role in atopic dermatitis (AD) predisposition. Toll like receptor (TLR) are important mediators between environment and immune system. There are incosnsitent studies about TLSR polymorphisms in AD. OBJECTIVE This study examined whether single nucleotide polimorphisms (SNPs) in the genes for TLR2 and TLR4 could be associated with the AD phenotypes and with its clinical...
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