Article

mRNA-Encoded TLR5 Agonist as an Immune Adjuvant

2026-06-01

Abstract excerpt

Activation of innate immunity enhances adaptive immune responses and underlies the mechanism of action of vaccine adjuvants. First-generation mRNA vaccines lack a dedicated adjuvant, relying instead on the self-adjuvanting properties of lipid nanoparticles (LNPs), and are thus expected to benefit from additional engagement of innate immune pathways not activated by LNPs. Among innate immune modulators, TLR5 agonis...

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Literature Corpus work: 20202ba6-29ce-5b4b-8ccb-3fc9a2f6db77
DOI: 10.64898/2026.05.30.728968

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