Article
MicroRNA-133 Modulates the β 1 -Adrenergic Receptor Transduction Cascade
7 May 2014
Abstract excerpt
RATIONALE: The sympathetic nervous system plays a fundamental role in the regulation of myocardial function. During chronic pressure overload, overactivation of the sympathetic nervous system induces the release of catecholamines, which activate β-adrenergic receptors in cardiomyocytes and lead to increased heart rate and cardiac contractility. However, chronic stimulation of β-adrenergic receptors leads to...
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