Article
Analysis of multiple SNPs in genetic association studies: comparison of three multi-locus methods to prioritize and select SNPs.
Genetic epidemiology - 1 Dec 2007
Heidema A Geert, Feskens Edith J M, Doevendans Pieter A F M, Ruven Henk J T, van Houwelingen Hans C, Mariman Edwin C M, Boer Jolanda M A
Abstract excerpt
Nonparametric approaches have been developed that are able to analyze large numbers of single nucleotide polymorphisms (SNPs) in modest sample sizes. These approaches have different selection features and may not provide similar results when applied to the same dataset. Therefore, we compared the results of three approaches (set association, random forests and multifactor dimensionality reduction [MDR]) to select...
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