Article
No association of TDP-43 with sporadic frontotemporal dementia.
Neurobiology of aging - 1 Jan 2009
Schumacher Axel, Friedrich Patricia, Diehl-Schmid Janine, Ibach Bernd, Perneczky Robert, Eisele Tamara, Vukovich Ruth, Foerstl Hans, Riemenschneider Matthias
Abstract excerpt
A hyperphosphorylated, ubiquitinated form of TDP-43, known as pathologic TDP-43, was shown to be a central component of ubiquitin-positive, tau-negative and alpha-synuclein-negative inclusions in frontotemporal lobar degeneration (FTLD-U) and amytrophic lateral sclerosis (ALS). To investigate the role of the TDP-43 gene in sporadic forms of frontotemporal dementia (FTD), we genotyped 10 single nucleotide...
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