Article
[FTLD/ALS as TDP-43 proteinopathies].
Rinsho shinkeigaku = Clinical neurology - 1 Nov 2010
Ishihara Tomohiko, Ariizumi Yuko, Shiga Atsushi, Yokoseki Akio, Sato Tatsuya, Toyoshima Yasuko, Kakita Akiyoshi, Takahashi Hitoshi, Nishizawa Masatoyo, Onodera Osamu
Abstract excerpt
Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) often coexist in the same patients: FTLD/MND. However, it is unclear whether FTLD/MND can be distinguished from ALS or FTLD. TAR DNA binding protein 43 KDa (TDP-43) has been identified as the major component of the ubiquitin-positive inclusion bodies in ALS, FTLD, and FTLD/MND. On the basis of this finding, a new concept of...
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