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Article

TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis.

PloS one - 11 Jun 2008

Guerreiro Rita J, Schymick Jennifer C, Crews Cynthia, Singleton Andrew, Hardy John, Traynor Bryan J

Abstract excerpt

BACKGROUND: TAR DNA binding protein, encoded by TARDBP, was shown to be a central component of ubiquitin-positive, tau-negative inclusions in frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). Recently, mutations in TARDBP have been linked to familial and sporadic ALS. METHODOLOGY/PRINCIPAL FINDINGS: To further examine the frequency of mutations in TARDBP in sporadic ALS, 279 ALS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18545701
DOI: 10.1371/journal.pone.0002450
PMCID: PMC2408729

Genes

TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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