Article
Absence of TARDBP gene mutations in an italian series of patients with frontotemporal lobar degeneration.
Dementia and geriatric cognitive disorders - 1 Jan 2009
Gallone Salvatore, Giordana Maria Teresa, Scarpini Elio, Rainero Innocenzo, Rubino Elisa, Fenoglio Pierpaola, Galimberti Daniela, Grifoni Silvia, Venturelli Eliana, Acutis Pier Luigi, Peletto Silvia, Maniaci Maria Grazia, Ferrero Patrizia, Zotta Michela, Pinessi Lorenzo
Abstract excerpt
BACKGROUND/AIM: Recent studies showed that TAR DNA-binding protein 43 (TDP-43), encoded by the TARDBP gene, is a major pathological protein in both sporadic and familial frontotemporal lobar degeneration (FTLD). The aim of this study was to search for mutations of the TARDBP gene in the disease....
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