Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discrimination of sheep susceptible and resistant to transmissible spongiform encephalopathies by an haplotype specific monoclonal antibody.

Journal of virological methods - 1 Nov 2007

Bilheude J M, Brun A, Morel N, Díaz San Segundo F, Lecroix S, Espinosa J C, González L, Steele P, Grassi J, Andréoletti O, Torres J M

Abstract excerpt

In the present report, the selective detection of sheep PrP haplotypes by monoclonal antibody 2A11 is described. It is showed that the substitution of glutamine by arginine but not by histidine at ovine PrP position 171 abolishes completely the recognition of either PrP(c) or PrP(d) by mAb 2A11, in such a way that the application of this antibody allows the unambiguous discrimination of R(171) homozygotes. On the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Cattle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme-Linked Immunosorbent Assay

Share to Prion Diseases

Share to Prions

Share to Scrapie

Share to Sheep, Domestic

Share to United Kingdom

Source

Identifiers

PMID: 17614145
DOI: 10.1016/j.jviromet.2007.05.026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discrimination of sheep susceptible and resistant to transmissible spongiform encephalopathies by an haplotype specific monoclonal antibody.PMID 17614145Read ↗

Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie.Semantic proximity Read ↗

Rapid analysis of allelic variants of the sheep PrP gene by oligonucleotide probes.Semantic proximity Read ↗

Ovine prion protein variant A(136)R(154)L(168)Q(171) increases resistance to experimental challenge with bovine spongiform encephalopathy agent.Semantic proximity Read ↗

Diagnosis and PrP genotype target of scrapie in clinically healthy sheep of Massese breed in the framework of a scrapie eradication programme.Semantic proximity Read ↗

Lysine at position 222 of the goat prion protein inhibits the binding of monoclonal antibody F99/97.6.1.Semantic proximity Read ↗

A real-time polymerase chain reaction assay to detect single nucleotide polymorphisms at codon 171 in the prion gene for the genotyping of scrapie susceptibility in sheep.Semantic proximity Read ↗

Proteinase K-resistant material in ARR/VRQ sheep brain affected with classical scrapie is composed mainly of VRQ prion protein.Semantic proximity Read ↗

PrP genotype in Sarda breed sheep and its relevance to scrapie. Brief report.Semantic proximity Read ↗

First confirmed sheep scrapie with A136R154Q171 genotype in Slovakia.Semantic proximity Read ↗

Association between natural scrapie and PrP genotype in a flock of Suffolk sheep in Scotland.Semantic proximity Read ↗

Protective effect of the T112 PrP variant in sheep challenged with bovine spongiform encephalopathy.Semantic proximity Read ↗

PRNP variants in goats reduce sensitivity of detection of PrP(Sc) by immunoassay.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.