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Article

Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck.

Cancer - 15 Aug 2007

Li Chunying, Hu Zhibin, Lu Jiachun, Liu Zhensheng, Wang Li-E, El-Naggar Adel K, Sturgis Erich M, Spitz Margaret R, Wei Qingyi

Abstract excerpt

BACKGROUND: Tobacco smoke contains numerous carcinogens that cause DNA damage, including oxidative lesions that are removed effectively by the base-excision repair (BER) pathway, in which adenosine diphosphate ribosyl transferase (ADPRT), x-ray repair cross-complementing 1 (XRCC1), and apurinic/apyimidinic endonuclease (APE1) play key roles. Genetic variations in the genes encoding for these DNA repair enzymes...

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Source

Identifiers

PMID: 17614107
DOI: 10.1002/cncr.22861

Genes

XRCC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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