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Article

Single-nucleotide polymorphisms in nucleotide excision repair genes, cigarette smoking, and the risk of head and neck cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2013

Wyss Annah B, Herring Amy H, Avery Christy L, Weissler Mark C, Bensen Jeannette T, Barnholtz-Sloan Jill S, Funkhouser William K, Olshan Andrew F

Abstract excerpt

BACKGROUND: Cigarette smoking is associated with increased head and neck cancer (HNC) risk. Tobacco-related carcinogens are known to cause bulky DNA adducts. Nucleotide excision repair (NER) genes encode enzymes that remove adducts and may be independently associated with HNC, as well as modifiers of the association between smoking and HNC. METHODS: Using population-based case-control data from the Carolina Head...

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Identifiers

PMID: 23720401
DOI: 10.1158/1055-9965.EPI-13-0185
PMCID: PMC3766549

Genes

ERCC6
DDB2
ERCC3
ERCC4
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