Article
Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression.
Immunity - 1 Jul 2007
Otsuka Motoyuki, Jing Qing, Georgel Philippe, New Liguo, Chen Jianming, Mols Johann, Kang Young Jun, Jiang Zhengfan, Du Xin, Cook Ryan, Das Subash C, Pattnaik Asit K, Beutler Bruce, Han Jiahuai
Abstract excerpt
Dicer is essential for plant, Caenorhabditis elegans, and Drosophila antiviral responses because of its role in generating small interfering RNA (siRNA) from viral genomes. We show that because of impaired miRNA production, mice with a variant Dicer1 allele (Dicer1(d/d)) were more susceptible to vesicular stomatitis virus (VSV) infection. We did not detect VSV genome-derived siRNA in wild-type cells or any...
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