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Article

Drosha as an interferon-independent antiviral factor

28 Apr 2014

Abstract excerpt

Utilization of antiviral small interfering RNAs is thought to be largely restricted to plants, nematodes, and arthropods. In an effort to determine whether a physiological interplay exists between the host small RNA machinery and the cellular response to virus infection in mammals, we evaluated antiviral activity in the presence and absence of Dicer or Drosha, the RNase III nucleases responsible for generating...

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PMID: 24778219
DOI: 10.1073/pnas.1319635111

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