Article

Non-canonical contribution of human Dicer helicase domain in antiviral innate immune response

2023-08-23

Abstract excerpt

<h4>ABSTRACT</h4> In mammalian somatic cells, the relative contribution of RNAi and the type I interferon response during viral infection is unclear. The apparent inefficiency of antiviral RNAi might be due to self-limiting properties and mitigating co-factors of the key enzyme Dicer. In particular, the helicase domain of human Dicer appears to be an important restriction factor of its activity. We studied the in...

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Literature Corpus work: 8863fb55-a7fb-58c1-8799-611a877c133e
DOI: 10.1101/2023.08.23.554407

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