Article
Variability in the kinesin light chain 1 gene may influence risk of age-related cataract.
Molecular vision - 27 Jun 2007
Andersson Malin E, Zetterberg Madeleine, Tasa Gunnar, Seibt-Palmér Mona, Juronen Erkki, Teesalu Pait, Blennow Kaj, Zetterberg Henrik
Abstract excerpt
PURPOSE: Kinesin-mediated cargo vesicle transport is fundamental to the maintenance of a proper lens fiber structure, which is essential for the transparency of the lens. Here, we test the hypothesis that the rs8702 polymorphism in the kinesin light chain 1 gene (KLC1), previously linked to Alzheimer disease (AD), may play a role in cataractogenesis. METHODS: Patients with nuclear (n=76), cortical (n=154),...
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