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Article

Decreased expression of claudin-1 correlates with recurrence status in breast cancer

1 Aug 2007

Abstract excerpt

Claudins (CLDNs) constitute the major transmembrane proteins of tight junctions. It may be hypothesized that changes in or loss of expression of tight junctional proteins such as CLDNs can lead to cellular disorientation and detachment, which is commonly seen in neoplasia. Recent studies have suggested that claudin-1 (CLDN1) plays an important role in invasion and metastasis and claudin-4 (CLDN4) has a particular...

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PMID: 17611630
DOI: 10.3892/ijmm.20.2.139

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