Article
[Is there a claudin-low phenotype of breast cancer?]
Arkhiv patologii - 1 Jan 2022
Popova O P, Kuznetsova A V, Bogomazova S Yu, Ivanov A A
Abstract excerpt
The novel molecular subtype of breast cancer (BC), named "claudin-low", was described in 2007. It was characterized by the consistently low expression of genes involved in the formation of epithelial tight junctions in combination with the high activation of genes associated with the epithelial-to-mesenchymal transition, as well as tumor stem cell markers. The similar claudin- low subtype was later identified at...
Topics
- Biomarkers, Tumor
- Breast Neoplasms
- Claudins
- Cystadenocarcinoma, Serous
- Epithelial-Mesenchymal Transition
- Female
- Humans
- Neoplastic Stem Cells
- Phenotype