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Article

STAT1 deficiency in the heart protects against myocardial infarction by enhancing autophagy

29 Mar 2011

Abstract excerpt

Previous studies have shown that the transcription factor signal transducer and activator of transcription 1 (STAT1) activation is increased in primary cardiac myocytes exposed to simulated ischaemia/reperfusion injury. This promotes apoptotic cell death by enhancing the expression of pro-apoptotic proteins. Autophagy has been demonstrated to play a cardioprotective role in the heart following myocardial...

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PMID: 21447043
DOI: 10.1111/j.1582-4934.2011.01323.x

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