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Article

Role of a sodium-dependent symporter homologue in the thermosensitivity of beta-lactam antibiotic resistance and cell wall composition in Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Feb 2008

Sieradzki Krzysztof, Chung Marilyn, Tomasz Alexander

Abstract excerpt

Expression of high-level beta-lactam resistance is known to be thermosensitive in many methicillin-resistant Staphylococcus aureus (MRSA) strains, including strain COL, in which the high methicillin MIC for cultures grown at 37 degrees C (800 microg/ml) was reduced to 12 microg/ml at 42 degrees C. COL grew faster at 42 degrees C than at 37 degrees C and at the higher temperature produced cell walls of abnormal...

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Identifiers

PMID: 18056270
DOI: 10.1128/AAC.00504-07
PMCID: PMC2224752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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