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Article

Isolation and mutation site determination of the temperature-sensitive murB mutants of Staphylococcus aureus.

FEMS microbiology letters - 16 May 2003

Matsuo Miki, Kurokawa Kenji, Nishida Satoshi, Li Yan, Takimura Haruto, Kaito Chikara, Fukuhara Norio, Maki Hideki, Miura Kenji, Murakami Kazuhisa, Sekimizu Kazuhisa

Abstract excerpt

The murB gene encodes UDP-N-acetylenolpyruvylglucosamine reductase and functions in bacterial peptidoglycan biosynthesis. A plasmid carrying the murB gene restored the temperature-sensitive growth of six Staphylococcus aureus mutants, in which peptidoglycan biosynthesis stopped at a restrictive temperature. Specific activity of UDP-N-acetylenolpyruvylglucosamine reductase in extracts from the mutants was lower...

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PMID: 12757953
DOI: 10.1016/S0378-1097(03)00260-X

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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