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Article

RET1-catalyzed uridylylation shapes the mitochondrial transcriptome in Trypanosoma brucei.

Molecular and cellular biology - 1 Mar 2010

Aphasizheva Inna, Aphasizhev Ruslan

Abstract excerpt

RNA uridylylation is critical for the expression of the mitochondrial genome in trypanosomes. Short U tails are added to guide RNAs and rRNAs, while long A/U heteropolymers mark 3' ends of most mRNAs. Three divergent mitochondrial terminal uridylyl transferases (TUTases) are known: RET1 catalyzes guide RNA (gRNA) uridylylation, RET2 executes U insertion mRNA editing, and MEAT1 associates with the editosome-like...

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Identifiers

PMID: 20086102
DOI: 10.1128/MCB.01281-09
PMCID: PMC2832499

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