Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

3p21.3 Tumor Suppressor Gene <i>H37/Luca15/RBM5</i> Inhibits Growth of Human Lung Cancer Cells through Cell Cycle Arrest and Apoptosis

1 Apr 2006

Abstract excerpt

Deletion at chromosome 3p21.3 is the earliest and the most frequently observed genetic alteration in lung cancer, suggesting that the region contains tumor suppressor gene(s) (TSG). Identification of those genes may lead to the development both of biomarkers to identify high-risk individuals and novel therapeutics. Previously, we cloned the H37/Luca15/RBM5 gene from 3p21.3 and showed its TSG characteristics. To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to RNA modifications and cancer
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16585163
DOI: 10.1158/0008-5472.can-05-1667

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

3p21.3 Tumor Suppressor Gene <i>H37/Luca15/RBM5</i> Inhibits Growth of Human Lung Cancer Cells through Cell Cycle Arrest and ApoptosisPMID 16585163Read ↗

Candidate tumor suppressor LUCA-15/RBM5/H37 modulates expression of apoptosis and cell cycle genesSemantic proximity Read ↗

The two single nucleotide polymorphisms in the H37/RBM5 tumour suppressor gene at 3p21.3 correlated with different subtypes of non-small cell lung cancers.Semantic proximity Read ↗

Genetic instability of RBM5/LUCA‐15/H37 in MCF‐7 breast carcinoma sublines may affect susceptibility to apoptosisSemantic proximity Read ↗

Mitochondrial uncoupler BAM15 attenuates cell proliferation and tumor growth in non-small cell lung cancerSemantic proximity Read ↗

<i>CUL7</i> Is a Novel Antiapoptotic OncogeneSemantic proximity Read ↗

TP53 gene status is a critical determinant of phenotypes induced by ALKBH3 knockdown in non-small cell lung cancers.Semantic proximity Read ↗

Knocking down the expression of Aurora-A gene inhibits cell proliferation and induces G2/M phase arrest in human small cell lung cancer cellsSemantic proximity Read ↗

A retroviral wild-type p53 expression vector penetrates human lung cancer spheroids and inhibits growth by inducing apoptosisSemantic proximity Read ↗

Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells.Semantic proximity Read ↗

Simultaneous acceleration of the cell cycle and suppression of apoptosis by splice variant delta‐6 of the candidate tumour suppressor LUCA‐15/RBM5Semantic proximity Read ↗

Activation of caspase-3 and cleavage of Rb are associated with p16-mediated apoptosis in human non-small cell lung cancer cellsSemantic proximity Read ↗

p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.