Article
Hot spots for molecular genetic alterations in lung cancer.
In vivo (Athens, Greece) - 1 Jan 2000
Pitterle D M, Jolicoeur E M, Bepler G
Abstract excerpt
Lung cancers are a heterogeneous group of tumors broadly classified as small cell or non-small cell lung cancers. In each case, numerous DNA mutations precede tumor formation, resulting in the activation of growth stimulatory genes and the loss of tumor suppressor genes. The known cellular functions of the tumor suppressor genes most commonly affected in lung cancer are reviewed herein, including the...
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