Hot spots for molecular genetic alterations in lung cancer.

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Article

Hot spots for molecular genetic alterations in lung cancer.

In vivo (Athens, Greece) - 1 Jan 2000

Pitterle D M, Jolicoeur E M, Bepler G

Abstract excerpt

Lung cancers are a heterogeneous group of tumors broadly classified as small cell or non-small cell lung cancers. In each case, numerous DNA mutations precede tumor formation, resulting in the activation of growth stimulatory genes and the loss of tumor suppressor genes. The known cellular functi...

Topics

Acid Anhydride Hydrolases
Animals
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 9
Cyclin-Dependent Kinase Inhibitor p16
DNA Damage
Genes, Tumor Suppressor
Genes, ras
Humans
Ligases
Loss of Heterozygosity
Lung Neoplasms
Mutation
Neoplasm Proteins
Nerve Tissue Proteins
Protein Tyrosine Phosphatases
Proteins

Source

Open in PubMed

Identifiers

PMID: 9891228

Genes

FHIT
PTPRG
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9891228-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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