Article
Autonomous Epinephrine Release by KCNJ5 Mutation Drives Familial Thoracic Aortic Aneurysm and Dissection.
Hypertension (Dallas, Tex. : 1979) - 1 Apr 2025
Duan Yanyu, Wu Chenglong, Lai Zhenghong, Yuan Qunxing, Hu Naixing, Liu Shaoqiang, Liu Ziyou
Abstract excerpt
BACKGROUND: The pathophysiology of familial thoracic aortic aneurysm and dissection (TAAD) is linked to genetic variants that affect aortic components. Although hypertension is a risk factor for TAAD, the precise genetic link remains unclear. METHODS: A family with autosomal dominant TAAD complicated by hypertension was studied to identify candidate mutations. The effect of the identified mutation on TAAD...
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