Article
Frequency of the LRRK2 G2019S mutation in siblings with Parkinson's disease.
Neuro-degenerative diseases - 1 Jan 2007
Lesage Suzanne, Leclere Laurence, Lohmann Ebba, Borg Michel, Ruberg Merle, Dürr Alexandra, Brice Alexis
Abstract excerpt
BACKGROUND: Mutations in the LRRK2 gene, the most frequent of which is the G2019S mutation in exon 41, cause familial and sporadic Parkinson's disease (PD) with reduced penetrance. OBJECTIVES: To assess the frequency of the LRRK2 G2019S mutation in families thought to have autosomal recessive PD...
Topics
- Aged
- DNA Mutational Analysis
- Europe
- Family Health
- Female
- Glycine
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged
- Mutation
- Parkinson Disease