Article
Frequency of the LRRK2 G2019S mutation in siblings with Parkinson's disease.
Neuro-degenerative diseases - 1 Jan 2007
Lesage Suzanne, Leclere Laurence, Lohmann Ebba, Borg Michel, Ruberg Merle, Dürr Alexandra, Brice Alexis
Abstract excerpt
BACKGROUND: Mutations in the LRRK2 gene, the most frequent of which is the G2019S mutation in exon 41, cause familial and sporadic Parkinson's disease (PD) with reduced penetrance. OBJECTIVES: To assess the frequency of the LRRK2 G2019S mutation in families thought to have autosomal recessive PD (siblings but not their parents were affected) and to determine the clinical features of LRRK2 mutation carriers....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.