Article
LRRK2 exon 41 mutations in sporadic Parkinson disease in Europeans.
Archives of neurology - 1 Mar 2007
Lesage Suzanne, Janin Sabine, Lohmann Ebba, Leutenegger Anne-Louise, Leclere Laurence, Viallet François, Pollak Pierre, Durif Franck, Thobois Stéphane, Layet Valérie, Vidailhet Marie, Agid Yves, Dürr Alexandra, Brice Alexis, Bonnet Anne-Marie, Borg Michel, Broussolle Emmanuel, Damier Philippe, Destée Alain, Martinez Maria, Penet Christiane, Rasco Olivier, Tison François, Tranchan Christine, Vérin Marc
Abstract excerpt
BACKGROUND: Mutations in leucine-rich repeat kinase 2 gene (LRRK2), particularly the G2019S mutation in exon 41, have been detected in familial and sporadic Parkinson disease (PD) cases. OBJECTIVES: To assess the frequency of LRRK2 exon 41 mutations in a series of sporadic PD cases from Europe and to determine the clinical features of LRRK2 mutation carriers. DESIGN: We analyzed European cases of sporadic PD for...
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