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Article

ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease.

Proceedings of the National Academy of Sciences of the United States of America - 12 Dec 2006

Ryu Hoon, Lee Junghee, Hagerty Sean W, Soh Byoung Yul, McAlpin Sara E, Cormier Kerry A, Smith Karen M, Ferrante Robert J

Abstract excerpt

Chromatin remodeling and transcription regulation are tightly controlled under physiological conditions. It has been suggested that altered chromatin modulation and transcription dysfunction may play a role in the pathogenesis of Huntington's disease (HD). Increased histone methylation, a well established mechanism of gene silencing, results in transcriptional repression. ERG-associated protein with SET domain...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17142323
DOI: 10.1073/pnas.0606373103
PMCID: PMC1748195

Genes

ERG
SET
SETDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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