ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease.

doi:10.1073/pnas.0606373103

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Article

ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease.

Proceedings of the National Academy of Sciences of the United States of America - 12 Dec 2006

Ryu Hoon, Lee Junghee, Hagerty Sean W, Soh Byoung Yul, McAlpin Sara E, Cormier Kerry A, Smith Karen M, Ferrante Robert J

Abstract excerpt

Chromatin remodeling and transcription regulation are tightly controlled under physiological conditions. It has been suggested that altered chromatin modulation and transcription dysfunction may play a role in the pathogenesis of Huntington's disease (HD). Increased histone methylation, a well es...

Topics

Aged
Animals
Cystamine
Female
Gene Expression
Histone-Lysine N-Methyltransferase
Histones
Humans
Huntington Disease
Male
Methylation
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Phenotype

Plicamycin

Promoter Regions, Genetic

Protein Methyltransferases

Sp3 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 17142323
DOI: 10.1073/pnas.0606373103
PMCID: PMC1748195

Genes

ERG
SET
SETDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-17142323-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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