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Article

A novel hypothesis for Alzheimer disease based on neuronal tetraploidy induced by p75 NTR

15 May 2010

Abstract excerpt

Cumulative evidence indicates that neuronal cell cycle re-entry represents an early and critical event in AD, recapitulating known hallmarks of the disease including tau hyperphosphorylation and production of Aβ peptide-containing plaques. Neurons that duplicate their DNA are rarely observed to undergo mitosis, and they remain for long time as tetraploid cells, in accordance with the chronic course of the...

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PMID: 20436277
DOI: 10.4161/cc.9.10.11582

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