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A Reevaluation of Tetraploidy in the Alzheimer’s Disease Brain

1 Jan 2009

Abstract excerpt

Alzheimer's disease (AD) is characterized by extensive neuronal death in distinct brain regions, including the frontal cortex and hippocampus, although the specific mechanisms of neuronal degeneration in AD remain a topic of intense scientific pursuit. One model for cell death in AD postulates that abortive cell cycle events in neurons, including tetraploidy, precede neuronal death, and novel therapeutics based...

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PMID: 19738367
DOI: 10.1159/000236901

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