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Article

Cryptococcus neoformans Site-2 protease is required for virulence and survival in the presence of azole drugs.

Molecular microbiology - 1 Nov 2009

Bien Clara M, Chang Yun C, Nes W David, Kwon-Chung Kyung J, Espenshade Peter J

Abstract excerpt

In the human fungal pathogen Cryptococcus neoformans, the SREBP orthologue Sre1 is important for adaptation and growth in nutrient-limiting host tissues. In this study, we characterize the C. neoformans serotype A Sre1 and its activating protease, Stp1. We demonstrate that Stp1 is a functionally conserved orthologue of the mammalian Site-2 protease and that Stp1 cleaves Sre1 within its predicted first...

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Identifiers

PMID: 19818023
DOI: 10.1111/j.1365-2958.2009.06895.x
PMCID: PMC2917040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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