Article
Smoking habit and interleukin lB C-31T polymorphism.
Journal of epidemiology - 1 May 2001
Hamajima N, Katsuda N, Matsuo K, Saito T, Ito L S, Ando M, Inoue M, Takezaki T, Tajima K
Abstract excerpt
Recent studies suggest that smoking habit may relate to genetic traits. This study examines the association with a polymorphism (C-31T) of interleukin 1B (IL-1B), which encodes IL-1beta, a multifunctional pro-inflammatory cytokine. Since the T allele makes a TATA box, the allele is thought to be responsible for a higher potency of IL-1B expression, indicating that individuals harboring the T allele are prone to...
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