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Article

A polymorphism of C-to-T substitution at -31 IL1B is associated with the risk of advanced gastric adenocarcinoma in a Japanese population.

Journal of human genetics - 1 Jan 2006

Ikehara Sanae Kabata, Ikehara Yuzuru, Matsuo Keitaro, Hirose Kaoru, Niwa Toru, Ito Hidemi, Ito Seiji, Kodera Yasuhiro, Yamamura Yoshitaka, Nakanishi Hayao, Tatematsu Masae, Tajima Kazuo

Abstract excerpt

Proinflammatory cytokine gene polymorphisms have been demonstrated to associate with gastric cancer risk, of which IL1B-31T/C and -511C/T changes have been well investigated due to the possibility that they may alter the IL1B transcription. The signal transduction target upon interleukin 1 beta (IL1beta) stimulation, the nuclear factor of kappa B (NFkappaB) activation, supports cancer development, signal...

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PMID: 17006606
DOI: 10.1007/s10038-006-0040-2

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FAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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