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Article

Genetic variants of chemokine receptor CCR7 in patients with systemic lupus erythematosus, Sjogren's syndrome and systemic sclerosis.

BMC genetics - 22 Jun 2007

Kahlmann Daniel, Davalos-Misslitz Ana Clara Marques, Ohl Lars, Stanke Frauke, Witte Torsten, Förster Reinhold

Abstract excerpt

BACKGROUND: The chemokine receptor CCR7 is a key organizer of the immune system. Gene targeting in mice revealed that Ccr7-deficient animals are severely impaired in the induction of central and peripheral tolerance. Due to these defects, Ccr7-deficient mice spontaneously develop multi-organ autoimmunity showing symptoms similar to those observed in humans suffering from connective tissue autoimmune diseases....

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Source

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Identifiers

PMID: 17587445
DOI: 10.1186/1471-2156-8-33
PMCID: PMC1913537

Genes

CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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