Article

Molecular determinants underlying DS2 activity at δ-containing GABA <sub>A</sub> receptors

2021-01-21

Abstract excerpt

Delta selective compound 2 (DS2) is one of the most widely used tools to study selective actions mediated by δ subunit-containing GABA A receptors. DS2 was discovered over 10 years ago, but despite great efforts, the precise molecular site of action has remained elusive. Using a combination of computational modeling, site-directed mutagenesis and cell-based pharmacological assays, we probed three potential bindi...

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Literature Corpus work: b63515a6-475d-5b58-bb09-3260e3c50706
DOI: 10.1101/2021.01.21.427670

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