Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach.

Behavior genetics - 1 Jul 2012

Derringer Jaime, Krueger Robert F, Dick Danielle M, Aliev Fazil, Grucza Richard A, Saccone Scott, Agrawal Arpana, Edenberg Howard J, Goate Alison M, Hesselbrock Victor M, Kramer John R, Lin Peng, Neuman Rosalind J, Nurnberger John I, Rice John P, Tischfield Jay A, Bierut Laura J

Abstract excerpt

Genome-wide studies of psychiatric conditions frequently fail to explain a substantial proportion of variance, and replication of individual SNP effects is rare. We demonstrate a selective scoring approach, in which variants from several genes known to directly affect the dopamine system are considered concurrently to explain individual differences in cocaine dependence symptoms. 273 SNPs from eight...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Cocaine-Related Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopamine

Share to Dopamine beta-Hydroxylase

Share to Genetic Association Studies

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Share to Receptors, Dopamine

Source

Open in PubMed Open full text

Identifiers

PMID: 22358648
DOI: 10.1007/s10519-012-9531-4
PMCID: PMC3416038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach.PMID 22358648Read ↗

The validity of cocaine dependence subtypes.Semantic proximity Read ↗

Comparing the utility of homogeneous subtypes of cocaine use and related behaviors with DSM-IV cocaine dependence as traits for genetic association analysis.Semantic proximity Read ↗

Post-GWAS analysis of six substance use traits improves the identification and functional interpretation of genetic risk loci.Semantic proximity Read ↗

Genetic Addiction Risk Score (GARS): molecular neurogenetic evidence for predisposition to Reward Deficiency Syndrome (RDS).Semantic proximity Read ↗

Examining the role of common genetic variants on alcohol, tobacco, cannabis and illicit drug dependence: genetics of vulnerability to drug dependence.Semantic proximity Read ↗

Large scale association analysis for drug addiction: results from SNP to gene.Semantic proximity Read ↗

Substance dependence low-density whole genome association study in two distinct American populations.Semantic proximity Read ↗

Multi-variant Genetic Panel for Genetic Risk of Opioid Addiction.Semantic proximity Read ↗

Genetic Architecture and Molecular Neuropathology of Human Cocaine Addiction.Semantic proximity Read ↗

Hatching the behavioral addiction egg: Reward Deficiency Solution System (RDSS)™ as a function of dopaminergic neurogenetics and brain functional connectivity linking all addictions under a common rubricSemantic proximity Read ↗

Novel insights into the common heritable liability to addiction: a multivariate genome-wide association studySemantic proximity Read ↗

Genome-wide association analysis of opioid use disorder: A novel approach using clinical data.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.