Article
The glycine transporter 1 gene (GLYT1) is associated with methamphetamine-use disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2008
Morita Yukitaka, Ujike Hiroshi, Tanaka Yuji, Kishimoto Makiko, Okahisa Yuko, Kotaka Tatsuya, Harano Mutsuo, Inada Toshiya, Komiyama Tokutaro, Hori Toru, Yamada Mitsuhiko, Sekine Yoshimoto, Iwata Nakao, Iyo Masaomi, Sora Ichiro, Ozaki Norio, Kuroda Shigetoshi
Abstract excerpt
Glycine transporter (GlyT)-1 plays a pivotal role in maintaining the glycine level at the glutamatergic synapse. Glycine is an allosteric agonist of N-methyl-D-aspartate (NMDA) receptors. Because activation of NMDA receptors is an essential step for induction of methamphetamine dependence and psychosis, differences in the functioning of GlyT-1 due to genetic variants of the GlyT-1 gene (GLYT1) may influence...
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