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Article

Association study of polymorphisms in glycine transporter with schizophrenia.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Oct 2006

Tsai S-J, Cheng C-Y, Hong C-J, Liao D-L, Hou S-J, Yen F-C, Liou Y-J

Abstract excerpt

Glycine acts as an obligatory co-agonist with glutamate on N-methyl-D-aspartate (NMDA) receptors. Brain glycine availability is determined by glycine transporters (GlyT1 or SLC6A9), which mediate glycine reuptake into nerve terminals. Since hypofunction of NMDA receptors has been implicated in the pathophysiology of schizophrenia, this study tests the hypothesis that GlyT1 genetic variants confer susceptibility...

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Identifiers

PMID: 16604304
DOI: 10.1007/s00702-006-0438-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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