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Article

Epigenetic inactivation ofMCJ (DNAJD1) in malignant paediatric brain tumours

27 Jul 2005

Abstract excerpt

MCJ (DNAJD1) is a recently discovered member of the DNAJ protein family whose expression is controlled epigenetically by methylation of a CpG island located within the 5' transcribed region of its gene. Methylation-dependent transcriptional silencing of MCJ has been observed in ovarian cancers and associated with increased resistance to chemotherapeutic agents; however, its role in other cancer types has not been...

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PMID: 16049974
DOI: 10.1002/ijc.21353

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