Integrative Genomic Analysis Identifies <i>NDRG2</i> as a Candidate Tumor Suppressor Gene Frequently Inactivated in Clinically Aggressive Meningioma

Abstract excerpt

Although meningiomas are common central nervous system tumors, little is known about the genetic events responsible for malignant progression. In this study, we employed gene expression profiling to identify transcripts whose expression was lost in anaplastic (WHO grade III) versus benign (WHO grade I) meningioma. Approximately 40% of genes down-regulated in anaplastic meningioma were localized to chromosomes 1p...

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