Article
Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific.
Neuro-oncology - 1 Aug 2009
Jun Peter, Hong Chibo, Lal Anita, Wong Judith M, McDermott Michael W, Bollen Andrew W, Plass Christoph, Held William A, Smiraglia Dominic J, Costello Joseph F
Abstract excerpt
Both genetic and epigenetic mechanisms contribute to meningioma development by altering gene expression and protein function. To determine the relative contribution of each mechanism to meningioma development, we used an integrative approach measuring copy number and DNA methylation changes genomewide. We found that genetic alterations affected 1.9%, 7.4%, and 13.3% of the 691 loci studied, whereas epigenetic...
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