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Article

Complement factor B polymorphism 32W protects against age-related macular degeneration.

Molecular vision - 20 Apr 2011

Hughes Anne E, Mullan Gemma M, Bradley Declan T

Abstract excerpt

PURPOSE: The 32Q (rs641153; A) and 32W (rs12614; T) variants of complement factor B (CFB) cause less efficient complement activation in vitro than the common 32R variant. This is thought to be the reason that the 32Q variant is associated with decreased risk of age-related macular degeneration (AMD). We investigated whether the 32W variant was also associated with decreased risk of AMD. METHODS: We genotyped 367...

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Source

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Identifiers

PMID: 21541267
PMCID: PMC3084221

Genes

CFB
CFH
HTRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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