Article
Prochondrogenic signals induce a competence for Runx2 to activate hypertrophic chondrocyte gene expression
18 Jun 2007
Abstract excerpt
Whereas Runx2 is necessary for bone formation and cartilage hypertrophy, it is unclear why Runx2 induces markers of chondrocyte hypertrophy only in chondrocytes. We document that chondrocytes either contain a cofactor, which can be induced in somitic cells by prochondrogenic signals, that is necessary for Runx2 to induce chondrocyte hypertrophy or, alternatively, lack a repressor of this maturation program....
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