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Article

Nkx3.2-mediated Repression of Runx2 Promotes Chondrogenic Differentiation

10 Feb 2005

Abstract excerpt

Runx2, a transcription factor known to be essential for osteoblast maturation and skeletogenesis, is also expressed in pre-cartilaginous mesenchymal condensations in the developing embryo. It is therefore necessary to understand the control and consequential regulatory activity of the Runx2 gene within the context of chondrogenic differentiation of a mesenchymal progenitor cell. We identify the homeodomain...

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PMID: 15703179
DOI: 10.1074/jbc.m411144200

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nkx3.2-mediated Repression of Runx2 Promotes Chondrogenic DifferentiationPMID 15703179Read ↗

Prochondrogenic signals induce a competence for Runx2 to activate hypertrophic chondrocyte gene expressionSemantic proximity Read ↗

Transcriptional control of chondrocyte fate and differentiationSemantic proximity Read ↗

Dominance of SOX9 function over RUNX2 during skeletogenesisSemantic proximity Read ↗

Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis.Semantic proximity Read ↗

BMP2 Commitment to the Osteogenic Lineage Involves Activation of Runx2 by DLX3 and a Homeodomain Transcriptional NetworkSemantic proximity Read ↗

Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytesSemantic proximity Read ↗

Role of Runx genes in chondrocyte differentiation.Semantic proximity Read ↗

Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal developmentSemantic proximity Read ↗

Notch1 signaling regulates Sox9 and VEGFA expression and governs BMP2-induced endochondral ossification of mesenchymal stem cellsSemantic proximity Read ↗

Nell-1, a key functional mediator of Runx2, partially rescues calvarial defects in <i>Runx2</i> <i>+</i>/<i>−</i> miceSemantic proximity Read ↗

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.Semantic proximity Read ↗

Runx3/AML2/Cbfa3 Regulates Early and Late Chondrocyte DifferentiationSemantic proximity Read ↗

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